Updated in 6/29/2013 11:46:54 PM      Viewed: 105 times      (Journal Article)
The Journal of clinical investigation 117 (5): 1137-46 (2007)

Immune surveillance of tumors.

Jeremy B Swann , Mark J Smyth
ABSTRACT
The ability of the immune system to identify and destroy nascent tumors, and to thereby function as a primary defense against cancer, has been debated for many decades. Recent findings by a number of investigators in both mouse models of cancer and humans with cancer now offer compelling evidence that particular immune cell types, effector molecules, and pathways can sometimes collectively function as extrinsic tumor suppressor mechanisms. This work provides the basis for further study of natural immunity to cancer and for rational use of this information in the design of immunotherapies in combination with other conventional cancer treatments.
DOI: 10.1172/JCI31405      ISSN: 0021-9738