Updated in 8/23/2010 5:12:22 AM      Viewed: 97 times      (Journal Article)
European journal of obstetrics, gynecology, and reproductive biology 148 (2): 177-81 (2010)

Clinical and morphological factors predictive of occult involvement of the nipple-areola complex in mastectomy specimens.

Paulo R Pirozzi , Claudia Rossetti , Ivo Carelli , Carlos A Ruiz , Luciano M Pompei , SebastiĆ£o Piato
OBJECTIVE: To evaluate characteristics predictive of nipple-areola complex (NAC) involvement by the breast tumor. STUDY DESIGN: Cases of infiltrative ductal carcinoma (stages I, IIA and IIB) treated by mastectomy in which the distance between the tumor and the NAC was >or=2 cm were included. NAC involvement was evaluated using serial histological sections. The distance between the tumor and the NAC was measured on mammograms. Other parameters taken into consideration were: tumor size, histological and nuclear grades, vascular invasion, and the presence of an in situ component. For comparisons between categorical variables, the chi-square test or Fisher's exact test were used. Student's t-test was used for numerical variables with normal distribution and the Mann-Whitney U-test was applied when distribution was not normal. RESULTS: Fifty patients were included. NAC was affected in 12 and unaffected in 38. There was no statistically significant difference in mean age between the unaffected and affected groups (58.9+/-13.5 years versus 55.8+/-12.5 years, p=0.477); however, 13.2% and 58.3% (p=0.046) in the NAC-unaffected and NAC-affected groups, respectively, were <50 years of age. Distance
DOI: 10.1016/j.ejogrb.2009.10.021      ISSN: 0301-2115