Updated in 11/10/2015 7:16:42 PM      Viewed: 261 times      (Journal Article)
Gastroenterology: S0016-5085 (2015)

Chronic Infection With Camelid Hepatitis E Virus in a Liver-transplant Recipient Who Regularly Consumes Camel Meat and Milk

GH Lee , BH Tan , EC Teo , SG Lim , YY Dan , A Wee , PP Aw , Y Zhu , ML Hibberd , CK Tan , MA Purdy , CG Teo
ABSTRACT
There have been increasing reports of food-borne zoonotic transmission of hepatitis E virus (HEV) genotype 3, which causes chronic infections in immunosuppressed patients. We performed phylogenetic analyses of the HEV sequence (partial and full-length) from 1 patient from the Middle East who underwent liver transplantation, and compared these with other orthohepevirus A sequences. We found the patient to be infected by camelid HEV. This patient regularly consumed camel meat and milk, so camelid HEV, which is genotype 7, might infect humans. Our finding links consumption of camel-derived food products to post-transplantation hepatitis E, which, if detected at early stages, can be cured with antiviral therapy and reduced administration of immunosuppressive agents.Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.