Updated in 9/15/2008 11:58:53 AM      Viewed: 120 times      (Journal Article)
The Journal of experimental medicine 205 (1): 155-68 (2008)

Characterization of a late transitional B cell population highly sensitive to BAmediated homeostatic proliferation

A. Meyer-Bahlburg , S. F. Andrews , K. O. Yu , S. A. Porcelli , D. J. Rawlings
We have characterized a distinct, late transitional B cell subset, CD21(int) transitional 2 (T2) B cells. In contrast to early transitional B cells, CD21(int) T2 B cells exhibit augmented responses to a range of potential microenvironmental stimuli. Adoptive transfer studies demonstrate that this subset is an immediate precursor of both follicular mature and marginal zone (MZ) B cells. In vivo, a large percentage of CD21(int) T2 B cells has entered the cell cycle, and the cycling subpopulation exhibits further augmentation in mitogenic responses and B cell-activating factor of the TNF family (BAFF) receptor expression. Consistent with these features, CD21(int) T2 cells exhibit preferential responses to BAfacilitated homeostatic signals in vivo. In addition, we demonstrate that M167 B cell receptor (BCR) idiotypic-specific B cells are first selected within the cycling CD21(int) T2 population, ultimately leading to preferential enrichment of these cells within the MZ B cell compartment. These data, in association with the coordinate role for BAFF and microenvironmental cues in determining the mature BCR repertoire, imply that this subset functions as a unique selection point in peripheral B cell development.
ISSN: 1540-9538 (Electronic)     
Jan 21Characterization of a late transitional B cell population highly sensitive to BAmediated homeostatic proliferation18180309AI063537/AI/United States NIAID AI45889/AI/United States NIAID CA81140/CA/United States NCI HD37091/HD/United States NICHD Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United Stateseng