Updated in 4/19/2011 12:05:07 PM      Viewed: 483 times      (Journal Article)
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 17 (6): 714-22 (2009)

Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs.

M Pei , F He , B M Boyce , V L Kish
ABSTRACT
Synovium-derived stem cells (SDSCs) have proven to be superior in cartilage regeneration compared with other sources of mesenchymal stem cells. We hypothesized that conventionally passaged SDSCs can be engineered in vitro into cartilage tissue constructs and the engineered premature tissue can be implanted to repair allogeneic full-thickness femoral condyle cartilage defects without immune rejection.
DOI: 10.1016/j.joca.2008.11.017      ISSN: 1063-4584