Updated in 4/22/2011 10:25:26 AM      Viewed: 39 times      (Journal Article)
Current opinion in biotechnology 9 (5): 470-5 (1998)

Adeno-associated virus expression systems for gene transfer.

J E Rabinowitz , J Samulski
ABSTRACT
In contrast to other gene delivery systems, adeno-associated virus vectors show long term gene expression without immune response or toxicity. New production methods have increased vector titers and eliminated adenovirus contamination, thereby facilitating effective in vivo use. These advancements will expedite additional animal model studies providing validation for use of this vector in human clinical trials.