Updated in 9/18/2015 10:57:03 AM      Viewed: 460 times      (Journal Article)
The spine journal : official journal of the North American Spine Society (2015)

Bone-marrow derived mesenchymal stem cells assembled with low dose BMP-2 in a three dimensional hybrid construct enhances posterolateral spinal fusion in syngeneic rats.

Tao Hu , Sunny Akogwu Abbah , Soo Yein Toh , Ming Wang , Raymond Wing Moon Lam , Mathanapriya Naidu , Gajadhar Bhakta , Simon Cool , Kishore Bhakoo , Jun Li , James Cho-Hong Goh , Hee-Kit Wong
ABSTRACT
The combination of potent osteoinductive growth factor, functional osteoblastic cells and osteoconductive materials to induce bone formation is a well-established concept in bone tissue engineering. However, supraphysiological dose of growth factor, such as recombinant human bone morphogenetic protein 2 (rhBMP-2), necessary in contemporary clinical application, have been reported to result in severe side effects.
ISSN: 1878-1632