Updated in 10/10/2012 3:17:02 PM      Viewed: 486 times      (Journal Article)
The Journal of surgical research 171 (1): 66-70 (2011)

Protection of Human Myocardium by Bone Marrow Cells: Role of Long-Term Administration of the Mitochondrial K(ATP) Channel Opener Nicorandil.

Vien Khach Lai , Manuel Galiñanes
ABSTRACT
We have previously demonstrated that bone marrow cells (BMCs) afford myocardial protection as potent as ischemic preconditioning (IP) and also that the myocardium of patients treated with the mitoK(ATP) channel opener nicorandil cannot be protected by IP. Here, we investigated whether nicorandil influences the cardioprotection elicited by BMCs and whether any loss in protection can be rescued by naïve allogenic BMCs.
DOI: 10.1016/j.jss.2009.12.029      ISSN: 0022-4804