Updated in 6/17/2012 11:54:48 AM      Viewed: 472 times      (Journal Article)
Nature 486: 215–221 (2012)

A framework for human microbiome research

Contributers List (http://www.nature.com/nature/journal/v486/n7402/full/nature11209.html#/contrib-auth)
ABSTRACT
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A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resulting in a broad range of quality-controlled resources and data including standardized methods for creating, processing and interpreting distinct types of high-throughput metagenomic data available to the scientific community. Here we present resources from a population of 242 healthy adults sampled at 15 or 18 body sites up to three times, which have generated 5,177 microbial taxonomic profiles from 16S ribosomal RNA genes and over 3.5 terabases of metagenomic sequence so far. In parallel, approximately 800 reference strains isolated from the human body have been sequenced. Collectively, these data represent the largest resource describing the abundance and variety of the human microbiome, while providing a framework for current and future studies.
ISSN: 0028-0836     
Notes

The Human Microbiome Project.

The aim of the HMP is to characterize microbial communities found at multiple human body sites and to look for correlations between changes in the microbiome and human health. More information can be found in the menus above and on the NIH Common Fund site.

In the news:

1. Scientists map bacteria living inside us (CBC)

2. Study seeks to map the microbes that live in and on us (The Boston Globe)

3. U.S. scientists map genes of microbes in healthy people (Chicago Tribune)