Updated in 1/12/2011 4:10:41 PM      Viewed: 117 times      (Journal Article)
Cardiovascular research 73 (3): 488-96 (2007)

Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts.

Sandrine V Pierre , Changjun Yang , Zhaokan Yuan , Jennifer Seminerio , Christian Mouas , Keith D Garlid , Pierre Dos-Santos , Zijian Xie
Because ouabain activates several pathways that are critical to cardioprotective mechanisms such as ischemic preconditioning, we tested if this digitalis compound could protect the heart against ischemia-reperfusion injury through activation of the Na+,K+-ATPase/c-Src receptor complex.
DOI: 10.1016/j.cardiores.2006.11.003      ISSN: 0008-6363